CD53 (CD53 molecule)
نویسندگان
چکیده
منابع مشابه
Recurrent infectious diseases in human CD53 deficiency.
We report a familiar syndrome of recurrent heterogeneous infectious diseases, caused by bacteria, fungi, and viruses, which has as its only detectable defect the lack of CD53 antigen expression in neutrophils. All other assays ruled out known causes of recurrent infectious diseases due to either leukocyte adhesion or phagocytosis defects. CD53 belongs to the transmembrane-4 superfamily of prote...
متن کاملCross-linking of CD53 promotes activation of resting human B lymphocytes.
The CD53 pan-leukocyte glycoprotein is a member of the recently described tetraspan family of cell membrane proteins. The structure and functional characteristics of these molecules indicate that they may play important roles in transmembrane signaling in different cells. Recently, it was reported that cross-linking of CD53 on human B cells led to an increase in cytoplasmic calcium fluxes. In t...
متن کاملThe human CD53 gene, coding for a four transmembrane domain protein, maps to chromosomal region 1p13.
Domain Protein, Maps to Chromosomal Region lp13 M. Eugenia Gonzalez, Fernando Pardo-Manuel de Villena, Elena Fernandez-Ruiz, Santiago Rodriguez de Cordoba, and Pedro A. Lazo Unidad de Genética Molecular (CSIC), Centro Nacional de Biología Celular y Retrovirus, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain, Centro de Investigaciones Biológicas, CSIC, Velazquez 144, and Servicio...
متن کاملPhysiological activation of human neutrophils down-regulates CD53 cell surface antigen.
Tetraspanin transmembrane proteins have a metastasis suppressor effect by acting as cell motility brakes in tumor cells. CD53 is a panleukocyte antigen that belongs to the tetra-span superfamily. Human neutrophils express high levels of CD53. We tested the hypothesis that this antigen level changes when cells are activated. Treatment of human neutrophils with their physiological activators, tum...
متن کاملThe Tetraspanin CD53 Modulates Responses from Activating NK Cell Receptors, Promoting LFA-1 Activation and Dampening NK Cell Effector Functions
NK cells express several tetraspanin proteins, which differentially modulate NK cell activities. The tetraspanin CD53 is expressed by all resting NK cells and was previously shown to decrease NK cell cytotoxicity upon ligation. Here, we show that CD53 ligation reduced degranulation of rat NK cells in response to tumour target cells, evoked redirected inhibition of killing of Fc-bearing targets,...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/38550